In addition, the analysis of the relationship between clinicopathological features of patients with OSCC and the expression of miR‐218 and GREM1 showed that the expressions of miR‐218 and GREM1 were closely related to LNM and TNM stage (both P < 0.05) but had no relationship with patient age or gender, or the size of OSCC tumour and degree of differentiation (Table 3). This evidence concerns the gene GREM1 and neoplasm.