Functional annotation of 3 leading variants from loci shared between MSA and IBD/CD as identified in conjFDR analysis (conjFDR < 0.05) showed that 1 variant (rs4957144) is in the first intron of the C7 gene, whereas 2 others, rs12740041 and rs116843836, are intergenic variants located upstream of the corresponding DENND1B and RSPO4 genes (Table 1). Here, DENND1B is linked to multiple system atrophy.