A recently published study identified genetic variability in the C7 gene as a major risk factor for AD in the Han Chinese population.52 In addition, the complementary system has been shown to be implicated in a diverse range of functions, including amyloid-beta (Aβ) clearance, microglia activation, neuroinflammation, apoptosis, and neuron death.53,54 We observed notable colocalization of conjFDR association and eQTL signals for the DENND1B gene in brain and blood (Fig. S5). This evidence concerns the gene DENND1B and Alzheimer disease.