C7 and synucleinopathy: In addition, a PLP-hαSyn transgenic model of MSA-P-like neurodegeneration showed significant disturbance of C7 expression in the midbrain (Fig. 4), a region specifically characterized by early neuroinflammatory response and neuronal loss linked to oligodendroglial α-synucleinopathy.35 This converging evidence suggests the involvement of C7 in MSA pathogenesis, which will necessitate further clarification by detailed functional analyses.