NPPB and hydrops fetalis: Although empagliflozin had no effect on change in VAS dyspnoea, diuretic response, serum NT-proBNP and length of hospital stay it was deemed to be safe, increased urinary output and reduced a combined endpoint of in-hospital worsening HF, rehospitalization for HF or death at 60 days compared with placebo [4 (10%) versus 13 (33%); p = .014] [50].