In view of the observations that mesenchymal non‐small cell lung carcinoma cancers are likely to be resistant to epidermal growth factor receptor and PI3 K/AKT inhibitors,49 and that the EMT/CSC phenotype could cause mTORC1 inhibitor resistance,50 it is possible that DNMT1 haploinsufficiency in cells is associated with resistance to mTOR pathway inhibition. This evidence concerns the gene EGFR and cancer.