DNMT3B and nonpapillary renal cell carcinoma: Indeed, in TCGA cohort of ccRCC patients, DNA methyltransferase (DNMT1, DNMT3A, and DNMT3B) alterations were detected in ~8% of entire cohort, and the mutation burden in tumors with them are significantly larger than those in tumors without (Figure S5).28, 29, 47