Indeed, in TCGA cohort of ccRCC patients, DNA methyltransferase (DNMT1, DNMT3A, and DNMT3B) alterations were detected in ~8% of entire cohort, and the mutation burden in tumors with them are significantly larger than those in tumors without (Figure S5).28, 29, 47. This evidence concerns the gene DNMT3A and nonpapillary renal cell carcinoma.