CD4 and neoplasm: Using CIBERSORT [29] and the LM22 signature gene (Table S5) to quantify the proportion of each individual immune cell type, we found that KS patients had significantly lower estimated proportions of CD8 and activated CD4 memory T cells than either K (P = 0.015 and 0.035) or KP (P = 0.043 and 0.023), indicating an immunosuppressive tumor microenvironment in the KS patients (Figs 6 and S2).