As a receptor tyrosine kinase and frequently overexpressed on the tumour‐initiating cell population in glioma, EPHA3 modulates mitogen‐activated protein kinase signalling to maintain glioblastoma cells in a less differentiated state, and once it is knocked down, tumorigenic potential of tumour cells is weaken.16 The gene discussed is EPHA3; the disease is glioblastoma.