Metabolic stress can suspend aerobic glycolysis via suppressing PFKP activity and direct glucose flux into the pentose phosphate pathway (PPP); on the other hand, NADPH of PPP could resist metabolic stress and enable survival of tumour cells, while knockdown of PFKP rescued cell death caused by loss of Snail under metabolic stress.27 The gene discussed is PFKP; the disease is neoplasm.