Although many APT/carcinomas exhibit histological features consistent with increased proliferation (Ki-67 index > 3%, increased mitotic count, and p53 expression) (4), and coexistence of 2 of the 3 markers is associated with increased risk of tumor progression and recurrence (39), the presence of these features does not fully predict future aggressive behavior (40, 41). This evidence concerns the gene MKI67 and neoplasm.