Somatic ATRX gene mutations are associated with several different tumor types, including astrocytomas in adults (21) and neuroendocrine tumors (NETs) such as pancreatic NETs (22, 23), neuroblastomas (24), and paragangliomas/pheochromocytomas (25, 26). This evidence concerns the gene ATRX and astrocytoma (excluding glioblastoma).