Crosstalk between the AR and DNA repair pathways has been extensively described.60–62 First, PARP is involved in androgen-dependent transcription and PARPi, therefore, impair this process.63 Second, the AR pathway regulates the transcription of DNA repair genes; androgen depletion, therefore, impairs HRR,60 which might render the tumour susceptible to PARPi, regardless of HRR mutation status. This evidence concerns the gene PARP1 and neoplasm.