BRCA2 and neoplasm: In this series, the incidence of tumour staging upgrades at 2, 5 and 10 years was 27%, 50% and 78% in BRCA2 carriers compared with 10%, 22% and 40% in non-carriers (P = 0.001).26 These results indicate that active surveillance might not be an appropriate management for germline BRCA2 carriers with tumours classified as “low risk”.