We have shown that expression of certain genes specific to AIS in CD8(+) T-cells provided 66%, 87%, and 100% clinical sensitivity for 2.4 h, 5 h, and 24 h following stroke onset33, suggesting that mRNA expression differences indicative of AIS have improved clinical sensitivity with time as more leukocytes respond to an inflammatory insult. This evidence concerns the gene CD8A and Stroke.