We selected a gene cluster identified by Adamski et al.7, which consisted of five genes: FOS, VCAN, PLBD1, MMP9, and CA4. This gene panel evaluated in CD8(+) T-cells has shown statistically significant differences (p = 1.42 × 10–5) in mRNA expression between AIS patients and controls7. The gene discussed is CA4; the disease is androgen insensitivity syndrome.