To test whether similar mechanisms underly the Tip60 neuroplasticity gene repression we observed in the brains of PD, HD and ALS Drosophila models, we carried out ChIP-qPCR using Abs to Tip60 and HDAC2 to assess their recruitment at these same genes the PD, HD, and ALS larval heads. The gene discussed is HDAC2; the disease is amyotrophic lateral sclerosis.