Interestingly, we also observed that sh is reduced in Htt128 OE, but not in SNCA or Vap-33 OE models while dlg is altered in SNCA, but not in Htt128 OE or Vap-33 OE, suggesting that sh reduction may be linked to HD, whereas dlg reduction may be linked to PD. The gene discussed is VAPA; the disease is Parkinson disease.