To test whether increasing Tip60 levels would also rescue the locomotor deficits observed in HD, PD and ALS Drosophila models, we generated a 201Y-Gal4; UAS-Tip60 (201Y; Tip60) model system that enables us to modulate Tip60 HAT levels specifically in the MB, in vivo. Here, KAT5 is linked to amyotrophic lateral sclerosis.