Similar to AD, each of the repressed Tip60 target neuroplasticity genes (futsch, dlg, sh, dsh) showed reduced Tip60 binding as well as loss of acetylation at cognition linked Tip60 mediated H4K12 and H4K16 acetylation marks in comparison to healthy wild-type flies of identical developmental staging. The gene discussed is KAT5; the disease is Alzheimer disease.