We next used ChIP to assess acetylation enrichment at four repressed synaptic plasticity gene loci (sh, dlg, futsch, dsh) in PD, HD and ALS larval brains using Abs to well characterized Tip60-mediated cognition linked histone acetylated (Ac) marks AcH4K12 and AcH4K16. This evidence concerns the gene KAT5 and Parkinson disease.