HDAC1 and amyotrophic lateral sclerosis: We observed a significant increase in HDAC2 (Rpd3) mRNA levels in HD, PD and ALS Drosophila larval brain (Fig. 2A: (t(4) = 5.675, p = 0.0048, unpaired t-test); Fig. 2B: (t(4) = 4.676, p = 0.0095, unpaired t-test); Fig. 2C: (t(4) = 3.904, p = 0.0175, unpaired t-test) in comparison to wild-type control brains.