To test whether increasing Tip60 HAT activity could rescue learning and STM defects observed in HD and PD and ALS Drosophila larvae, we crossed fly strains expressing either Htt(128Q), SNCAA30P or Vap-33-1 with 201Y;Tip60 for co-expression of disease-associated proteins and Tip60 in the mushroom body of the progeny. This evidence concerns the gene KAT5 and Huntington disease.