Since the connection between NOD2 and uveitis underscores an essential function for NOD2 in ocular homeostasis, we sought to delineate the cellular mechanism by which Nod2 disruption causes uveitis using experimental autoimmune uveitis (EAU), in which mice are immunized with the retinal antigen, interphotoreceptor retinoid-binding protein (IRBP)17. Here, RBP3 is linked to autoimmune uveitis.