NOD2 and uveitis: While the role for Nod2 in promotion of Th-immunity is well-known8, our work extends the previously ascribed antimicrobial, MDP-sensing function of Nod2 in APCs and Th-priming, to also include one as a T cell-intrinsic modulator of the TCR-signaling axis in autoreactive Th17 cells that cause uveitis.