Similar to peripherally-derived CD4+ T cells (Fig. 5a, b), Nod2−/− thymocytes elicited a more severe uveitis compared to WT thymocytes (Fig. 5g), and recapitulated the T cell-intrinsic signature of augmented IL-17 production to IRBP-stimulation in vitro (Fig. 5h). This evidence concerns the gene CD4 and uveitis.