IL6 and multiple sclerosis: For example, rapamycin exhibits a high neuroprotective activity by suppressing nuclear factor-κB activity75; rapamycin can improve the quality of life of patients with multiple sclerosis by decreasing interferon-γ76; rapamycin attenuates mouse food allergy through inhibition of the intestinal IL-9 production-mast cell survival axis77; rapamycin increase the expression and release of IL-6 (ref. 78).