TARDBP and amyotrophic lateral sclerosis: The second compound, pimozide, is a neuroleptic that has been used as an anti-psychotic agent for many years, and was recently identified by our group in a chemical-genetic screen for TDP-43 toxicity in ALS, and was validated in a small phase IIa clinical trial (ClinicalTrials.gov Identifier: NCT02463825; Patten et al., 2017).