Notably, spastin reduction was observed upon HIPK2 depletion in murine neuron-like NSC34 differentiated cells (Figs 1D and S1B and C), in human SH-SY-5Y neuron-like differentiated cells (data not shown) and in primary cortical neurons explanted from CRE-inducible Hipk2 KO mice upon infection with an adenovirus expressing the recombinase CRE (Figs 1E and S1D), showing that spastin levels are regulated by HIPK2 in postmitotic differentiated primary neurons. The gene discussed is HIPK2; the disease is infection.