In a separate effort, following the development of C. elegans models of tauopathy by pan-neuronally expressing wild-type or FTD-associated mutant tau (tau-FTDP-17) (Kraemer et al., 2003), forward genetic screens identified two new molecular factors, SUT-1 and SUT-2, that participate in the activation of tau (Kraemer and Schellenberg, 2007; Guthrie et al., 2009). Here, MAPT is linked to frontotemporal dementia.