MAPT and Alzheimer disease: Furthermore, the analysis revealed 10 additional P-sites (Thr-373, Thr-377, Ser-400, Thr-403, Ser-413, Thr-414, Ser-416, Ser-422, Ser-433, and Ser-435; see Table S1) in the C-terminal domain of Tau, which have been reported for Tau from human AD brain (12, 13) but were absent in our previous studies.