Such toxicants induce CYP1A1 and ROS generation, leading to DNA damage as well as interleukin 8 (IL-8) production in keratinocytes, which may account for their carcinogenic properties, and IL-8-driven inflammatory skin disorders such as psoriasis and palmoplantar pustulosis, respectively [57]. Here, CXCL8 is linked to palmoplantar pustulosis.