The mild differences observed between the two tumor models could be related to their differences in CXCR4 overexpression level (higher in the Toledo DLBCL model, Supplementary Figure S6), but also, to the use of different mouse strains to develop them, since Swiss nude mice (used for the M5 CRC model) are more immunocompetent than NOD SCID mice (required for developing Toledo DLBCL model). Here, CXCR4 is linked to neoplasm.