Furthermore, Lactobacillus mucosae NK41, Bifidobacterium longum NK46, Lactobacillus reuteri NK33, and Bifidobacterium adolescentis NK98 isolated from healthy human feces have shown to exert antidepressant properties through normalization of gut microbial composition and immune system, suppressing inflammatory responses by inhibiting the NF-κB pathway, decreasing blood level of corticosterone, TNF-α, IL-6, and lipopolysaccharide levels in mice with immobilization stress-induced anxiety/depression [158,159]. The gene discussed is IL6; the disease is major depressive disorder.