Muscle atrophy attributed to disuse is associated with a shift in MyHC isoforms from slow-to-fast as evidenced by a decrease in MyHC slow (type I) and an increase in MyHC fast (type II) following a prolonged period of bedrest [30,38,39], a feature that does not seem to be present in ICUAW. The gene discussed is MYH6; the disease is muscle atrophy.