PIK3CA and cancer: Else, autophagy seems to limit the therapeutic effects of PI3K/Akt/mTOR signaling inhibitors; therefore, autophagy inhibition can theoretically overcome tumor resistance to these agents: combination of mTORC1 inhibitors plus CQ, show a synergistic effect on cell death in different cancers such as renal cancer [88] colon cancer [89] hepatocellular carcinoma [90] and glioma [91].