HIF1A and cancer: Hypoxia-inducible factor-1 (HIF-1) is responsible of response to hypoxia in cancer cells [167,168], and it has been reported that the expression of EMT and stemness activators such as WNT, Hedgehog, and NOTCH pathways, or stemness markers such as FOXA2, cMET, CD133, NANOG, SOX2, SOX17, and PDX1 could also occur through the activation of HIF-1 [169,170].