Moreover, rare cases of an inborn genetic component of neonatal seizures exist, with the majority altering metabolic pathways, including KCNQ2 mutations, infantile hypophosphatasia (mutations in the tissue nonspecific alkaline phosphatase (TNAP)) and propionic acidaemia (deficiency of propionyl-CoA carboxylase) [27]. The gene discussed is ALPL; the disease is hypophosphatasia.