Obesity is also associated with the production of several adipocytokines hypothesized to promote oncogenesis, including leptin, tumor necrosis factor-alpha (TNFα), interleukin-6 (IL-6), IL-7, and IL-8 [73,74,75,76,77]. This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.