FGG and Hypofibrinogenemia: However, there are still questions to be answered: (i) Is it indeed true that only mutations in the FGG gene are predisposing to intrahepatic accumulation?; (ii) concerning phenotypic manifestations, why does the same mutation behave differently in different individuals?; (iii) why are the clinical manifestations of hypofibrinogenemia almost exclusively related to liver damage?