Although there is a lack of evidence for the direct restoration of PTEN through manufactured demethylating agents in PTEN-silenced prostate cancer, the naturally occurring dietary compound resveratrol has been shown to promote PTEN acetylation and reactivation by inhibiting an interaction between the metastasis-associated protein 1 (MTA1) and histone deacetylase (HDAC) complex in prostate cancer cells [132]. This evidence concerns the gene PTEN and Familial prostate cancer.