SAR260301 was unable reduce AKT signaling due to rapid clearance (determined by an ex vivo platelet p-AKT-inhibition assay) (NCT01673737) [174], and AZD6482 has not been followed up clinically in an anti-tumor setting since its initial phase 1 safety and tolerability study performed >10 years ago (NCT00688714). The gene discussed is AKT1; the disease is neoplasm.