Although limited research has explored the therapeutic benefit of targeting MAN2C1, silencing of MAN2C1 by siRNA has been shown to induce apoptosis in esophageal carcinoma cells [110], while its suppression in nasopharyngeal carcinoma cells has been demonstrated to inhibit tumor formation and metastasis in vivo [111]. The gene discussed is MAN2C1; the disease is carcinoma of esophagus.