Because ~70% of colorectal cancers have CpG hypermethylated APC, the Fxrα1TG mouse model may be useful for studies of colorectal cancer prevention and treatment linked to HFD and silencing of APC. Finally, future studies should extend these investigations to the female gender for which differences in BA and microbiota related to diet and FXR have been documented [73]. This evidence concerns the gene NR1H4 and colorectal cancer.