BRAF and cutaneous melanoma: Nevertheless, many patients become secondarily resistant (i.e., their status reverts from “responder” to “non-responder”) upon treatment [3,6] and some develop important side effects among which is the onset of new primary BRAF wild type (BRAF-wt) cutaneous melanoma, likely due to the paradoxical activation of the MAPK pathway by BRAF inhibitors [5].