In order to include a very common clinical status of cutaneous metastatic melanoma observed in innate BRAF-m status patients treated for several months with BRAF inhibitors, we similarly assessed the cytotoxic efficacy of the 4 compounds on 3 generated vemurafenib-resistant cell lines, vemurafenib being an inhibitor of the BRAF enzyme used for the treatment of late-stage (IIIc and IV) melanoma (Table 3). Here, BRAF is linked to melanoma.