GCKR and myocardial ischemia: However, Varbo et al. [42] evaluate the association between GCKR-rs1260326 with lipid levels and risk of ischemic heart disease (IHD) and myocardial infarction (MI) in the general population, reporting that GCKR-rs1260326 did not influence low-density lipoprotein cholesterol levels or risk of IHD or MI.