Genetic variants in three genes involved in lipid and glucose metabolism, rs738409 (C/G) in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene, rs10401969 (T/C) in the transmembrane 6 superfamily member 2 (TM6SF2) gene, and rs1260326 (C/T) in the glucokinase regulatory protein (GCKR) gene, have been consistently associated with the risk of NAFLD and NAFLD hepatic complications. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.