Our review was conducted by searching phrases: “rs7041/rs4855 + disease”; vitamin d binding protein polymorphism; vitamin d binding protein polymorphism + disease; Gc globulin polymorphism + disease, rs7041/rs4855 + cancers; rs7041/rs4855 + chronic diseases; VDBP + disease; DBP + disease; 25-hydroxyvitamin D cancers; 25-hydroxyvitamin D + diseases; VDBP polymorphism disease; VDBP SNP disease. Here, GC is linked to cancer.