CD47 and diffuse large B-cell lymphoma: Indeed, CD47 and SIRPα blocking strategies are being studied in many ongoing trials and have demonstrated promising therapeutic effects in various malignancies, including DLBCL [5,208], AML, [3] and Sezary syndrome [209], with acceptable safety and toxicity profiles [NCT02216409] [NCT02953782] [NCT02678338] [NCT02953509] [NCT03248479] [NCT03013218] [NCT02663518].