Furthermore, neutrophil-mediated tumor cell killing was stronger using IgA compared to IgG antibodies for various cancer antigens, e.g., epithelial cellular adhesion molecule (EpCAM) (colon carcinoma) [128], human epidermal growth factor receptor-2 (HER-2) (mammary carcinoma) [129], EGFR (epithelial, colorectal, and renal cell carcinoma) [130], CD30 (B- and T-cell lymphoma) [131], HLA class II [132], and CD20 (B-cell lymphoma) in in vitro studies [127] and in vivo studies [133,134]. This evidence concerns the gene ERBB2 and hereditary clear cell renal cell carcinoma.