We have demonstrated that the downregulation of sirtuin1 can reduce PGC-1α expression, impair mitochondrial biogenesis, augment Complex I dysfunction, heighten the extent of oxidized proteins, increase caspase-3 expression, and promote neuronal cell damage in the hippocampus in kainic acid-induced status epilepticus [96]. This evidence concerns the gene PPARGC1A and status epilepticus.