TLR4 and Cognitive impairment: Several inflammatory mediators were shown to have critical roles in status epilepticus such as Toll-like receptor 4 (TLR4), high mobility group box 1(HMGB1), NF-kB, NLRP3, and iNOS which are induced during status epilepticus and predict the development of neuronal cell loss, cognitive deficits, mortality, the progress of chronic epilepsy [68].