CD40LG and postural orthostatic tachycardia syndrome: She also had a history of post-traumatic stress disorder (PTSD) secondary to a prolonged history of family trauma; postural orthostatic tachycardia syndrome (POTS)/dysautonomia (baseline BP 94/54 with a pulse rate of 80 beats per minute (BPM), which would decrease to 80/54 standing with a 20 point increase in pulse rate) with episodes of dizziness and pre-syncopal episodes; sleep apnea; and abnormal immunoglobulins (IgG 3 subclass deficiency (29 mg/dL, normal range 41–129) and elevated levels of IgM (303 mg/dL, normal range 40–230)).