Use of NAC, ALA, and GSH helped to decrease oxidative stress, support detoxification, and minimize the risk of methemoglobinemia [121,122,123], while doses of glutathione were increased to 2000 mg QD or BID along with alkalization (using sodium bicarbonate or fresh squeezed citrus) for Herxheimer reactions and/or any increased levels of methemoglobin [76,124,125]. This evidence concerns the gene HBG2 and methemoglobinemia.