Recently, Cicero et al. demonstrated in elderly subjects who consumed a symbiotic formula containing Lactobacillus plantarum PBS067, Lactobacillus acidophilus PBS066, and Lactobacillus reuteri PBS072 decreased serum markers associated with inflammation, such as C-reactive protein and tumor necrosis alpha-factor, as well as several risk factors associated with metabolic syndrome [35]. This evidence concerns the gene TNF and metabolic syndrome.