AFP and neoplasm: In contrast, unexpectedly, tumor-related factors (e.g., tumor size, extrahepatic metastasis, vascular invasion, or serum AFP values) were not found to be associated with prognosis in this study, which is in agreement with a recent study demonstrating that hepatic reserve function (Child-Pugh score and mALBI grade) but not tumor burden (TNM stage, vascular invasion, and AFP) was predictive of survival in 152 patients who received lenvatinib [15].