Analogously, freshly isolated human PAEC from idiopathic PAH patients displayed a marked pro-inflammatory transcriptional signature, including elevated expression of IL-1α, IL-6,IL-8, IL-12, MCP-1, E-selectin, ICAM-1, P-selectin and VCAM-1 [59]. The gene discussed is SELE; the disease is pulmonary arterial hypertension.