BCR and posterior cortical atrophy: In this retrospective study with three working phases (Figure 1), we identified differentially expressed circRNAs in PCa tissue samples using microarray analysis, performed an analytical validation of eight selected circRNAs and their linear counterparts via RT-qPCR measurements, and successfully elaborated RNA-signatures as discriminative biomarkers to differentiate between normal and cancerous PCa tissue and as predictive BCR biomarkers.