We also found that sphk-1 (p = 0.0086), spin-2 (p < 0.0001), and spin-3 (p < 0.0001) mutant worms were significantly more susceptible to infection by E. faecalis strain MMH594, whereas spin-4 (p = 0.0222) mutant worms were modestly more resistance than N2 (Figure 2A,C–E). This evidence concerns the gene SPHK1 and infection.