CCN1 and osteosarcoma: CCN1 was found to be involved in the vascularization and dissemination of by Habel et al. using a lentiviral transduction-induced CCN11 silencing system, the authors concluded that CCN1 silencing could reduce the tumor vasculature and limit the osteosarcoma metastatic capacity, indicating CCN1 is a critical contributor to the tumor vascularization [109].