CCN1 and lung cancer: Tong et al. (2004) reported that the mRNA level of CCN1 was decreased in 74 out of 94 lung tumor samples screened, comparing to the normal lung samples [102], and within various lung cancers, the non-small cell lung cancer (NSCLC) attracted most of the attention from researchers, since more than 80–85% of the lung tumors lie within this category [103].