They can modify the secretory profile of adipocytes, enhancing the secretion of multiple adipokines, cytokines, and chemokines, such as osteopontin, tumor necrosis factor alpha, interleukin-6, monocyte chemotactic protein-1, and metalloprotease 2, and reducing the secretion of protective adipokines, which can conversely lead to development, proliferation, progression, and migration of cancer cells [14,17,18,31,32,33,34]. Here, SPP1 is linked to cancer.