Aβ oligomers in Alzheimer’s disease [44,45], SOD1 mutants in Amyotrophic Lateral Sclerosis (ALS) [46,47,48], and α-syn in PD [49], all associate with the Voltage-Dependent Anion Channels (VDAC) isoform 1, reducing dramatically the mitochondria synthesized ATP availability [50]. Here, SOD1 is linked to early-onset autosomal dominant Alzheimer disease.