Circulating biomarkers of fibrosis are of high potential interest; in fact, as much as in heart failure, right ventricular remodeling in PAH involves not only the cardiomyocytes, but also non-myocyte cells and the extracellular matrix, and Gal-3 is a promoter of inflammation and fibrosis. The gene discussed is LGALS3; the disease is pulmonary arterial hypertension.