LGALS3 and systemic sclerosis: In this connective tissue disease characterized by progressive fibrosis of various organs, Gal-3 plasma levels are strictly linked to the evolution of the disease: Gal-3 levels have been shown to increase during the course of the disease and has been shown to be clearly associated with signs of the advanced organ sclerosis and laboratory parameters of inflammation, which could partially explain the prognostic power of this biomarker in SSc [22,23,24].