• Subacute onset of unilateral buttock or back pain with elevated CRP. Fever is usually absent or low grade• Risk factors: IV drug use, pelvic trauma, infectious endocarditis, immunosuppression, cutaneous or genitourinary infection• Imaging: on MRI, unilateral periarticular muscle edema, thick capsulitis, and extracapsular fluid collection may be useful in differentiating infectious sacroiliitis from sacroiliitis due to axSpA. The gene discussed is CRP; the disease is Fever.