High immunohistochemical expression of p53, MMP2, and MMP9, and low Ki-67 expression, the infiltrating growth pattern rather than growth by displacement (“pushing”) pattern, and unfavorable histology (usual type, basaloid, adenosquamous, and mixed and sarcomatoid squamous cell carcinoma) are variables associated with a higher risk of regional lymph-node metastases (Gunia et al. 2012; Zhu et al. 2007; Cubilla et al. 2001). The gene discussed is MMP2; the disease is sarcomatoid squamous cell carcinoma.