c-Myc directly regulates glutaminase, transcriptionally activates glutamine transporters and promotes glutamine metabolism including glutamine catabolism to glutamic acid for anaplerosis and NADPH and in cancer, transcriptionally coordinates glutaminolysis and dependence on exogenous glutamine that cannot be rescued by adding TCA intermediates [63, 65, 107–112]. The gene discussed is MYC; the disease is cancer.