Interestingly knockouts or dominant-negative mutations of TRα have been shown to decrease hepatic lipogenesis and triglyceride content and, in the former, to protect mice against high fat diet induced insulin resistance, whereas dominant negative mutations of TRβ are associated with increased hepatic lipogenesis, decreased hepatic β-oxidation, and increased hepatic steatosis [54, 55]. Here, THRB is linked to fatty liver disease.