We conclude that alternative splicing of NCoR exon 37 in the WT organism plays an important role in hepatic lipid deposition, with the continued expression of the NCoRω splice-variant in the NCoRδ-/- mice sufficient to prevent the severe hepatic steatosis associated with its ablation in the NCoRω-/- animals. Here, NCOR1 is linked to Hepatic steatosis.