UBE2L6 (also known as UbcH8 [21]) is an E2 ubiquitin/ISG15-conjugating enzyme that plays a determinative role in targeting c-Myc for proteasomal degradation by interacting with E3 ubiquitin ligase, thereby suppressing cell proliferation and xenograft tumor growth [22]. The gene discussed is UBE2L6; the disease is neoplasm.