Multiple aberrations in histone PTMs have been observed in leukemias and lymphomas, such as EZH2 mutations altering H3 K27 methylation [39], DOT1L dysregulation of H3 K79 methylation with MLL translocations [40], and KMT2D mutations affecting H3 K4 methylation [41]. The gene discussed is KMT2A; the disease is leukemia.