Genes identified through the Gxθ screen (Fig 3B) as potential candidates for cardiac fibrosis include: Crisp2 (rs6295287, p = 6.74E-7), a secreted biomarker of cardiovascular disease[31], Top2b (rs31538570, p = 2.14E-06), which plays a cardioprotective role in response to stress[32], Rarb (rs31538570, p = 2.14E-06), a known regulator of inflammation with unknown function in the heart[33], and Fibrosin (rs33146511, p = 2.54E-6), a major component of the fibrosis pathway[34]. The gene discussed is TOP2B; the disease is cardiovascular disorder.