Higher SHBG increased the risk of dementia or cognitive decline in male (N=6, RR=1.06, 95% CI=1.00-1.13, I2=24.8%), female (N=1, RR=1.30, 95% CI=1.10-1.70) and both genders (N=7, RR=1.10, 95% CI=1.01-1.20, I2=46.4%). The gene discussed is SHBG; the disease is dementia.