Since IL‐1β is a pro‐inflammatory cytokine which may contribute to the pathogenesis of inflammatory bowel disease (IBD) [28, 29, 30], while IL‐6 and IL‐10 are associated with colon epithelial cell proliferation [31, 32], we investigated the influence of CRAMP deficiency in myeloid or epithelial cells on the plasma levels of IL‐1β, IL‐6, and IL‐10 after DSS treatment. The gene discussed is IL6; the disease is inflammatory bowel disease.